All Services
Structure-Based Drug Discovery Service
Structure-Based Drug Discovery(SBDD) solution represents a comprehensive and highly integrated approach designed to accelerate the discovery process of pre-stage drugs. The solution incorporates multiple specialized product modules unified on an innovative structure-based drug discovery platform. The core content revolves around the following three main directions: (1)Structure-Based drug discovery: Large-scale virtual compound screening from identi
Protein MicroED Three-Dimensional Structure Analysis Service
Microelectron Diffraction (MicroED) represents the advanced technology for the 3D reconstruction of organic small molecules and biomacromolecules, such as proteins, utilizing electron diffraction data from Cryo-Transmission Electron Microscopy (Cryo-TEM). As a cutting-edge methodology, MicroED uses electrons as the incident beam to acquire microcrystal electron diffraction data from Cryo-TEM. Similar to diffraction methods like X-ray cr
High-Throughput X-ray Protein Crystallography Screen Service
X-ray crystallography is one of the most widely used techniques by structural biologists. As an important tool for revealing the chemical properties of crystals and the 3D structure of molecules, X-ray protein crystallography contributes a lot to the development of Protein Data Bank (PDB). PDB has collected more than 170,000 biological structural information of macromolecules. About 90% of the biological macromolecule atomic coordinate
Service for mAb Epitopes Mapping Using Cryo-EM
Therapeutic monoclonal antibodies (mAbs) play a substantial role in the biopharmaceutical market, accounting for more than 50% of therapeutic protein sales, and experiencing continuous growth. In the development of new vaccines, therapeutic antibodies, and diagnostic reagents, it is critical to select mAbs with the appropriate affinity, specificity, and biophysical properties. Applications of Cryo-EM-Based mAb Epitopes Mapping 1.Reveal
Protein Complex Cryo-EM Structure Analysis Service
Protein complex structure analysis is one of the methods used for reanalysis. It means that all target proteins or their homologous proteins already have high-resolution structures in the PDB database. It is relatively easy to analyze the structure of such proteins whose structures have been solved, including protein mutants, drug target proteins and small molecule compounds, protein-protein complexes and protein-nucleic acid complexes, etc. &nb
Cryo-EM Protein-Small Molecule Complex Structure Analysis Service
Structure analysis of protein-small molecule complex means that the target protein or its homologous protein has a high-resolution structure in the PDB database. It is more straightforward to analyze the structure of such proteins (including protein mutants, drug target proteins bound to small molecule compounds, protein-protein complexes, and protein-nucleic acid complexes, etc.). Workflow 1.Sample preparation and de
Cryo-EM Survey Standard Evaluation Service
Survey standard assessment is based on ideal negative staining results, and a second round of sample quality assessment is conducted based on preliminary cryo-electron microscopy data collection results. Survey standard assessment serves to evaluate whether the target protein sample is suitable for electron microscopy analysis, as well as the difficulty of electron microscopy analysis and the risk of the results. It is also an initial step for structure
Cryo-EM De Novo Structure Analysis Service
“De novo” is defined as de novo structure analysis, which means that the high-resolution structure of the target protein or its homologous protein has not been reported in the Protein Data Bank (PDB). Structural analysis of such proteins whose structures have not yet been determined (including proteins with unknown structures in the field of life sciences, protein complexes, and drug target proteins with unknown structures, etc.) is highly innovative and
Negative staining is a specialized method used to observe particulate substances or biomacromolecules in samples under a microscope. Once the sample has been purified, the degree of purification is assessed to determine suitability for further electron microscopy analysis. However, traditional biochemical assays may fall short in this regard. Even in cases where complexes maintain their structural integrity, they might represent a blend of subcomplexes with varying co